Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish

• Main Authors: Karin Tuschl (Author), Richard J. White (Author), Chintan Trivedi (Author), Leonardo E. Valdivia (Author), Stephanie Niklaus (Author), Isaac H. Bianco (Author), Chris Dadswell (Author), Ramón González-Méndez (Author), Ian M. Sealy (Author), Stephan C. F. Neuhauss (Author), Corinne Houart (Author), Jason Rihel (Author), Stephen W. Wilson (Author), Elisabeth M. Busch-Nentwich (Author)
• Format: Book
• Published: The Company of Biologists, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Manganese neurotoxicity is a hallmark of hypermanganesemia with dystonia 2, an inherited manganese transporter defect caused by mutations in SLC39A14. To identify novel potential targets of manganese neurotoxicity, we performed transcriptome analysis of slc39a14−/− mutant zebrafish that were exposed...