GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis

• Main Authors: Xuezhi Yang (Author), Yingjie Zhao (Author), Qi Wei (Author), Xuemin Zhu (Author), Luping Wang (Author), Wankang Zhang (Author), Xiaoyi Liu (Author), Jiajie Kuai (Author), Fengling Wang (Author), Wei Wei (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is an autoimmune disease with a complex etiology. Monocyte-derived macrophages (MDMs) infiltration are associated with RA severity. We have reported the deletion of G-protein-coupled receptor kinase 2 (GRK2) reprograms macrophages toward an anti-inflammatory phenotype by re...