Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity

• Egile Nagusiak: Xuemei Zhao (Egilea), Chengcai Xia (Egilea), Xiaodan Wang (Egilea), Hao Wang (Egilea), Ming Xin (Egilea), Long Yu (Egilea), Yulong Liang (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Cyclophilin J (CyPJ), also called peptidylprolyl isomerase like 3, has been identified as a novel member of the cyclophilin family. Our previous research has resolved the three-dimensional structure of CyPJ and demonstrated the peptidylprolyl cis-trans isomerase (PPIase) activity of CyPJ, which can...