The Glutathione Metabolite γ-Glutamyl-Glutamate Partially Activates Glutamate NMDA Receptors in Central Neurons With Higher Efficacy for GluN2B-Containing Receptors

• Prif Awduron: Fatiha Sebih (Awdur), Nawfel Mokrane (Awdur), Pierre Fontanel (Awdur), Mete Kayatekin (Awdur), Mahira Kaabeche (Awdur), Janique Guiramand (Awdur), Catherine Cohen-Solal (Awdur), Thierry Cens (Awdur), Matthieu Rousset (Awdur), Pierre Charnet (Awdur), Marie-Céleste De Jésus Ferreira (Awdur), Jean-Baptiste Thibaud (Awdur), Claudine Ménard (Awdur), Sonia Cantel (Awdur), Valérie Rolland (Awdur), Michel Vignes (Awdur), Julien Roussel (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2022-01-01T00:00:00Z.
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Gamma-L-glutamyl-L-glutamate (γ-Glu-Glu) was synthetized and further characterized for its activity on cultured neurons. We observed that γ-Glu-Glu elicited excitatory effects on neurons likely by activating mainly the N-methyl-D-aspartate (NMDA) receptors. These effects were dependent on the integr...