The Glutathione Metabolite γ-Glutamyl-Glutamate Partially Activates Glutamate NMDA Receptors in Central Neurons With Higher Efficacy for GluN2B-Containing Receptors

• Main Authors: Fatiha Sebih (Author), Nawfel Mokrane (Author), Pierre Fontanel (Author), Mete Kayatekin (Author), Mahira Kaabeche (Author), Janique Guiramand (Author), Catherine Cohen-Solal (Author), Thierry Cens (Author), Matthieu Rousset (Author), Pierre Charnet (Author), Marie-Céleste De Jésus Ferreira (Author), Jean-Baptiste Thibaud (Author), Claudine Ménard (Author), Sonia Cantel (Author), Valérie Rolland (Author), Michel Vignes (Author), Julien Roussel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gamma-L-glutamyl-L-glutamate (γ-Glu-Glu) was synthetized and further characterized for its activity on cultured neurons. We observed that γ-Glu-Glu elicited excitatory effects on neurons likely by activating mainly the N-methyl-D-aspartate (NMDA) receptors. These effects were dependent on the integr...