Exosomes Secreted from CXCR4 Overexpressing Mesenchymal Stem Cells Promote Cardioprotection via Akt Signaling Pathway following Myocardial Infarction

• Main Authors: Kai Kang (Author), Ruilian Ma (Author), Wenfeng Cai (Author), Wei Huang (Author), Christian Paul (Author), Jialiang Liang (Author), Yuhua Wang (Author), Tiejun Zhao (Author), Ha Won Kim (Author), Meifeng Xu (Author), Ronald W. Millard (Author), Zhili Wen (Author), Yigang Wang (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Objective. Exosomes secreted from mesenchymal stem cells (MSC) have demonstrated cardioprotective effects. This study examined the role of exosomes derived from MSC overexpressing CXCR4 for recovery of cardiac functions after myocardial infarction (MI). Methods. In vitro, exosomes fro...