Insights into the biosynthesis of septacidin l-heptosamine moiety unveils a VOC family sugar epimerase

• Main Authors: Meng Chen (Author), Zhengyan Guo (Author), Jinyuan Sun (Author), Wei Tang (Author), Min Wang (Author), Yue Tang (Author), Pengwei Li (Author), Bian Wu (Author), Yihua Chen (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

l-Heptopyranoses are important components of bacterial polysaccharides and biological active secondary metabolites like septacidin (SEP), which represents a group of nucleoside antibiotics with antitumor, antifungal, and pain-relief activities. However, little is known about the formation mechanisms...