Gene Expression Profile of High IFN-γ Producers Stimulated with Leishmania braziliensis Identifies Genes Associated with Cutaneous Leishmaniasis.

• Main Authors: Marcia W Carneiro (Author), Kiyoshi F Fukutani (Author), Bruno B Andrade (Author), Rebecca P Curvelo (Author), Juqueline R Cristal (Author), Augusto M Carvalho (Author), Aldina Barral (Author), Johan Van Weyenbergh (Author), Manoel Barral-Netto (Author), Camila I de Oliveira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susce...