Common Structural Pattern for Flecainide Binding in Atrial-Selective K_v1.5 and Na_v1.5 Channels: A Computational Approach

• Main Authors: Yuliet Mazola (Author), José C. E. Márquez Montesinos (Author), David Ramírez (Author), Leandro Zúñiga (Author), Niels Decher (Author), Ursula Ravens (Author), Vladimir Yarov-Yarovoy (Author), Wendy González (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Its treatment includes antiarrhythmic drugs (AADs) to modulate the function of cardiac ion channels. However, AADs have been limited by proarrhythmic effects, non-cardiovascular toxicities as well as often modest antiarrhythmic efficacy...