AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation

• Main Authors: Lijun Kong (Author), Hewei Zhang (Author), Chaosheng Lu (Author), Keqing Shi (Author), Hongjian Huang (Author), Yushu Zheng (Author), Yongqiang Wang (Author), Dan Wang (Author), Hongwei Wang (Author), Wei Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute pancreatitis (AP) is a highly fatal acute inflammation and is often accompanied by multiple organ dysfunction syndrome (MODS). The liver, one of the most vulnerable extrapancreatic organs in AP, is the major organ involved in the evolution of the disease and correlates strongly with the occurr...