Induction of Heme Oxygenase-1 by 15d-Prostaglandin J₂ Mediated via a ROS-Dependent Sp1 and AP-1 Cascade Suppresses Lipopolysaccharide-Triggered Interleukin-6 Expression in Mouse Brain Microvascular Endothelial Cells

• Main Authors: Chien-Chung Yang (Author), Li-Der Hsiao (Author), Ya-Fang Shih (Author), Ching-I Chang (Author), Chuen-Mao Yang (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heme oxygenase-1 (HO-1) has been shown to exert antioxidant, anti-inflammatory, and anti-apoptotic effects in various types of cells. Therefore, the induction of HO-1 is an excellent rationale for the development of protective drugs. 15-Deoxy-Δ^12,14-prostaglandin J<sub>2...