Induction of Heme Oxygenase-1 by 15d-Prostaglandin J₂ Mediated via a ROS-Dependent Sp1 and AP-1 Cascade Suppresses Lipopolysaccharide-Triggered Interleukin-6 Expression in Mouse Brain Microvascular Endothelial Cells

• Päätekijät: Chien-Chung Yang (Tekijä), Li-Der Hsiao (Tekijä), Ya-Fang Shih (Tekijä), Ching-I Chang (Tekijä), Chuen-Mao Yang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Heme oxygenase-1 (HO-1) has been shown to exert antioxidant, anti-inflammatory, and anti-apoptotic effects in various types of cells. Therefore, the induction of HO-1 is an excellent rationale for the development of protective drugs. 15-Deoxy-Δ^12,14-prostaglandin J<sub>2...