Discovery of novel FGF trap small molecules endowed with anti-myeloma activity

• Main Authors: Sara Taranto (Author), Riccardo Castelli (Author), Giuseppe Marseglia (Author), Laura Scalvini (Author), Federica Vacondio (Author), Alessandra Gianoncelli (Author), Giovanni Ribaudo (Author), Jessica Faletti (Author), Giorgia Gazzaroli (Author), Edoardo Rocca (Author), Roberto Ronca (Author), Marco Rusnati (Author), Antonio Sacco (Author), Aldo Maria Roccaro (Author), Marco Presta (Author), Marco Mor (Author), Arianna Giacomini (Author), Silvia Rivara (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibroblast growth factors (FGFs) act as proangiogenic and mitogenic cytokines in several cancers, including multiple myeloma (MM). Indeed, corrupted FGF autocrine and paracrine secretion induces an aberrant activation of the FGF receptor (FGFR) signaling sustaining cancer cell spreading and resistan...