Genomic loss in environmental and isogenic morphotype isolates of Burkholderia pseudomallei is associated with intracellular survival and plaque-forming efficiency.

• Main Authors: Natnaree Saiprom (Author), Tanes Sangsri (Author), Sarunporn Tandhavanant (Author), Sineenart Sengyee (Author), Rungnapa Phunpang (Author), Anucha Preechanukul (Author), Uriwan Surin (Author), Apichai Tuanyok (Author), Ganjana Lertmemongkolchai (Author), Wasun Chantratita (Author), T Eoin West (Author), Narisara Chantratita (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Burkholderia pseudomallei is an environmental bacterium that causes melioidosis. A facultative intracellular pathogen, B. pseudomallei can induce multinucleated giant cells (MNGCs) leading to plaque formation in vitro. B. pseudomallei can switch colony morphotypes unde...