The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1

• Main Authors: Andrew D. Biancolin (Author), Alexandre Martchenko (Author), Emilia Mitova (Author), Patrick Gurges (Author), Everan Michalchyshyn (Author), Jennifer A. Chalmers (Author), Alessandro Doria (Author), Josyf C. Mychaleckyj (Author), Alice E. Adriaenssens (Author), Frank Reimann (Author), Fiona M. Gribble (Author), Manuel Gil-Lozano (Author), Brian J. Cox (Author), Patricia L. Brubaker (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted from intestinal L-cells upon nutrient intake. While recent evidence has shown that GLP-1 is released in a circadian manner in rats, whether this occurs in mice and if this pattern is regulated by the circadian clock remain...