The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats

• Main Authors: María Miana (Author), María Galán (Author), Ernesto Martínez-Martínez (Author), Saray Varona (Author), Raquel Jurado-López (Author), Belén Bausa-Miranda (Author), Alfonso Antequera (Author), María Luaces (Author), José Martínez-González (Author), Cristina Rodríguez (Author), Victoria Cachofeiro (Author)
• Format: Book
• Published: The Company of Biologists, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Extracellular matrix (ECM) remodelling of the adipose tissue plays a pivotal role in the pathophysiology of obesity. The lysyl oxidase (LOX) family of amine oxidases, including LOX and LOX-like (LOXL) isoenzymes, controls ECM maturation, and upregulation of LOX activity is essential in fibrosis; how...