Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.

• Main Authors: Lionel Sacconnay (Author), Melissa Angleviel (Author), Giuseppe Marco Randazzo (Author), Marcos Marçal Ferreira Queiroz (Author), Emerson Ferreira Queiroz (Author), Jean-Luc Wolfender (Author), Pierre-Alain Carrupt (Author), Alessandra Nurisso (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T. cruzi, the protozoan responsible for Chagas...