Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.

Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.

BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T. cruzi, the protozoan responsible for Chagas...

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Main Authors: Lionel Sacconnay (Author), Melissa Angleviel (Author), Giuseppe Marco Randazzo (Author), Marcos Marçal Ferreira Queiroz (Author), Emerson Ferreira Queiroz (Author), Jean-Luc Wolfender (Author), Pierre-Alain Carrupt (Author), Alessandra Nurisso (Author)
Format: Book
Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
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3rd Floor Main Library

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