Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.

• Asıl Yazarlar: Lionel Sacconnay (Yazar), Melissa Angleviel (Yazar), Giuseppe Marco Randazzo (Yazar), Marcos Marçal Ferreira Queiroz (Yazar), Emerson Ferreira Queiroz (Yazar), Jean-Luc Wolfender (Yazar), Pierre-Alain Carrupt (Yazar), Alessandra Nurisso (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T. cruzi, the protozoan responsible for Chagas...