Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.
BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth of T. cruzi, the protozoan responsible for Chagas...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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Public Library of Science (PLoS),
2014-02-01T00:00:00Z.
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