Celastrol ameliorates ulcerative colitis-related colorectal cancer in mice via suppressing inflammatory responses and epithelial-mesenchymal transition

• Main Authors: Lianjie eLin (Author), Yan eSun (Author), Dongxu eWang (Author), Shihang eZheng (Author), Jing eZhang (Author), Changqing eZheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Celastrol, also named as tripterine, is a pharmacologically active ingredient extracted from the root of traditional Chinese herb Tripterygium wilfordii Hook F with potent anti-inflammatory and anti-tumor activities. In the present study, we investigated the effects of celastrol on ulcerative coliti...