Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model.

• Main Authors: Malick M Gibani (Author), Celina Jin (Author), Sonu Shrestha (Author), Maria Moore (Author), Lily Norman (Author), Merryn Voysey (Author), Elizabeth Jones (Author), Luke Blackwell (Author), Helena Thomaides-Brears (Author), Jennifer Hill (Author), Christoph J Blohmke (Author), Hazel C Dobinson (Author), Philip Baker (Author), Claire Jones (Author), Danielle Campbell (Author), Yama F Mujadidi (Author), Emma Plested (Author), Lorena Preciado-Llanes (Author), Giorgio Napolitani (Author), Alison Simmons (Author), Melita A Gordon (Author), Brian Angus (Author), Thomas C Darton (Author), Vincenzo Cerundulo (Author), Andrew J Pollard (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enteric fever is a systemic infection caused by Salmonella Typhi or Paratyphi A. In many endemic areas, these serovars co-circulate and can cause multiple infection-episodes in childhood. Prior exposure is thought to confer partial, but incomplete, protection against subsequent attacks of enteric fe...