Chimeric mRNA-based COVID-19 vaccine induces protective immunity against Omicron and Delta variants

• Main Authors: Qidong Hu (Author), Ying Zhao (Author), Namir Shaabani (Author), Xiaoxuan Lyu (Author), Colin Powers (Author), Haotian Sun (Author), Vincent Cruz (Author), Karen Stegman (Author), Jia Xu (Author), Amber Fossier (Author), Yu Huang (Author), Giang Ho (Author), Yi Kao (Author), Zhihao Wang (Author), Zhenping Wang (Author), Yue Hu (Author), Yi Zheng (Author), Lilian Kyaw (Author), Cipriano Zuluaga (Author), Hua Wang (Author), Hong Pei (Author), Robert Allen (Author), Hui Xie (Author), Henry Ji (Author), Runqiang Chen (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emerging SARS-CoV-2 variants of concern (VOCs) exhibit enhanced transmission and immune escape, reducing the effectiveness of currently approved mRNA vaccines. To achieve wider coverage of VOCs, we first constructed a cohort of mRNAs harboring a furin cleavage mutation in the spike (S) protein o...