A Dual PI3K/HDAC Inhibitor Downregulates Oncogenic Pathways in Hematologic Tumors In Vitro and In Vivo

• Main Authors: Zheng Yan (Author), Kehui Zhang (Author), Ming Ji (Author), Heng Xu (Author), Xiaoguang Chen (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Purpose: To investigate the efficacy and mechanism of compound 23, a PI3K/HDAC dual-target inhibitor, on hematologic tumor cells in vitro and in vivo. Methods: The MTS Kit was used to study the antiproliferative effects in vitro. Western blot was used to analyze the involved signaling pathways. Flow...