Combination of AZD3463 and DZNep Prevents Bone Metastasis of Breast Cancer by Suppressing Akt Signaling

• Váldodahkkit: Wenxin He (Dahkki), Xiankun Cao (Dahkki), Kewei Rong (Dahkki), Xiaojun Chen (Dahkki), Shuai Han (Dahkki), An Qin (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Osteolysis resulting from osteoclast overactivation is one of the severe complications of breast cancer metastasis to the bone. Previous studies reported that the anti-cancer agent DZNep induces cancer cell apoptosis by activating Akt signaling. However, the effect of DZNep on breast cancer bone met...