Modulation of HMGB1 Release in APAP-Induced Liver Injury: A Possible Strategy of Chikusetsusaponin V Targeting NETs Formation

• Main Authors: Jian Liu (Author), Min Jiang (Author), Quan Jin (Author), Yan-Ling Wu (Author), Zhen-Yu Cui (Author), Ben-Wen Cui (Author), Yue Shang (Author), Zi-Ying Zhan (Author), Yong-Ce Lin (Author), Jing-Ya Jiao (Author), Mei-Hua Piao (Author), Zhi-Hong Zhang (Author), Rong-Hui Sun (Author), Ji-Xing Nan (Author), Li-Hua Lian (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP), one of the most common antipyretic analgesics, which is safe at therapeutic dose, cause acute liver injury and even death at overdose. However, the mechanism of APAP-induced inflammation in liver injury is still controversial. Therefore, effective drug intervention is urgently...