DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice

• Main Authors: Charles Colas (Author), Mathilde Mouchiroud (Author), Manal Al Dow (Author), Alona Kolnohuz (Author), Yves Gélinas (Author), Alexandre Caron (Author), Mathieu Laplante (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth and metabolism. In mice, activation of mTOR controls cold adaptation by promoting the recruitment and the activation of brown adipose tissue (BAT). DEP-domain containing mTOR-interacting protein...