Brusatol increases chemotherapeutic drug efficacy in pancreatic ductal adenocarcinoma by suppressing Nrf2 signaling

• Główni autorzy: Juan Zhang (Autor), Hongxi Xu (Autor), Yulin Wu (Autor), William Chi Shing Cho (Autor), Yang Li (Autor), Peiyao Ren (Autor), Yanfang Xian (Autor), Zhixiu Lin (Autor)
• Format: Książka
• Wydane: Compuscript Ltd, 2024-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Chemoresistance to gemcitabine (Gem) remains a substantial obstacle in the treatment of pancreatic ductal adenocarcinoma carcinoma (PDAC). Nrf2, a transcription factor responsive to oxidative stress, has been implicated as a key contributor to chemoresistance. Previous studies have demonstrated anti...