Brusatol increases chemotherapeutic drug efficacy in pancreatic ductal adenocarcinoma by suppressing Nrf2 signaling

• Main Authors: Juan Zhang (Author), Hongxi Xu (Author), Yulin Wu (Author), William Chi Shing Cho (Author), Yang Li (Author), Peiyao Ren (Author), Yanfang Xian (Author), Zhixiu Lin (Author)
• Format: Book
• Published: Compuscript Ltd, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemoresistance to gemcitabine (Gem) remains a substantial obstacle in the treatment of pancreatic ductal adenocarcinoma carcinoma (PDAC). Nrf2, a transcription factor responsive to oxidative stress, has been implicated as a key contributor to chemoresistance. Previous studies have demonstrated anti...