The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

• Main Authors: Julia Bräunig (Author), Juliane Dinter (Author), Carolin S. Höfig (Author), Sarah Paisdzior (Author), Michal Szczepek (Author), Patrick Scheerer (Author), Mark Rosowski (Author), Jens Mittag (Author), Gunnar Kleinau (Author), Heike Biebermann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines. TAAR1 signaling is mainly mediated via activation of the Gs/adenylyl cyclase pathway....