Haploidentical CD7 CAR T-cells induced remission in a patient with TP53 mutated relapsed and refractory early T-cell precursor lymphoblastic leukemia/lymphoma

• Main Authors: Hai-ping Dai (Author), Wei Cui (Author), Qing-ya Cui (Author), Wen-juan Zhu (Author), Hui-min Meng (Author), Min-qing Zhu (Author), Xia-ming Zhu (Author), Lin Yang (Author), De-pei Wu (Author), Xiao-wen Tang (Author)
• Format: Book
• Published: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Patients with relapsed/refractory early T-cell precursor lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) respond poorly to traditional therapy and have dismal prognosis. CD7 is a promising therapeutic targets for chimeric antigen receptor modified T cell therapy (CART) due to its widely expre...