Integrated analyses reveal IDO1 as a prognostic biomarker coexpressed with PD-1 on tumor-associated macrophages in esophageal squamous cell carcinoma

• Main Authors: Yaojun Peng (Author), Lingxiong Wang (Author), Juan Yang (Author), Qiyan Wu (Author), Xiaoxuan Sun (Author), Jinying Zhang (Author), Yanju Yu (Author), Liping Zhang (Author), Jie Gao (Author), Qing Zhou (Author), Haiyan Zhu (Author), Fan Yin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundInhibition of indolamine-2,3-dioxygenase 1 (IDO1) has been proposed as a promising strategy for cancer immunotherapy; however, it has failed in clinical trials. Macrophages in the tumor microenvironment (TME) contribute to immune escape and serve as potential therapeutic targets. This stud...