Co-Delivery of Repurposing Itraconazole and VEGF siRNA by Composite Nanoparticulate System for Collaborative Anti-Angiogenesis and Anti-Tumor Efficacy against Breast Cancer

• Main Authors: Mingji Jin (Author), Bowen Zeng (Author), Yanhong Liu (Author), Lili Jin (Author), Yan Hou (Author), Chao Liu (Author), Wei Liu (Author), Hao Wu (Author), Liqing Chen (Author), Zhonggao Gao (Author), Wei Huang (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combinations of two different therapeutic modalities of VEGF inhibitors against angiogenesis can cooperatively impede breast cancer tumor growth and enhance therapeutic efficacy. Itraconazole (ITZ) is a conventional antifungal drug with high safety; however, it has been repurposed to be a multi targ...