The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis

• Main Authors: Xiaoxuan Zhong (Author), Xiang Wei (Author), Yan Xu (Author), Xuehai Zhu (Author), Bo Huo (Author), Xian Guo (Author), Gaoke Feng (Author), Zihao Zhang (Author), Xin Feng (Author), Zemin Fang (Author), Yuxuan Luo (Author), Xin Yi (Author), Ding-Sheng Jiang (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart disease. Here, we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum- and PDGF-BB-induced vascular smooth muscle cells (VSMCs), and in tissues of c...