When Unsuspected Crystallinity Ruins Biological Testing in Early Discovery: A Case Study

• Main Authors: Claudi de Rocafiguera (Author), Blanca Belsa (Author), Mercè Font-Bardia (Author), Cristina Puigjaner (Author), Eduard Serra (Author), Ana M. Cuartero-Albesa (Author), Raimon Puig de la Bellacasa (Author), José I. Borrell (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The impact of the crystalline or amorphous structure of a solid on the solubility and pharmacokinetic properties of a drug candidate is always considered by the pharmaceutical industry during the development of a new drug; however, it is not so frequently considered during the early drug discovery p...