The Use of Survival Dose-Rate Dependencies as Theoretical Discrimination Criteria for Dynamic Radiobiological Models

• Main Authors: Sergio Mingo Barba (Author), Fernando Lobo-Cerna (Author), Przemek M. Krawczyk (Author), Marco Lattuada (Author), Rudolf M. Füchslin (Author), Alke Petri-Fink (Author), Stephan Scheidegger (Author)
• Format: Book
• Published: SAGE Publishing, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction Cell repair dynamics are crucial in optimizing anti-cancer therapies. Various assays (eg, comet assay and γ-H2AX) assess post-radiation repair kinetics, but interpreting such data is challenging and model-based data analyses are required. However, ambiguities in parameter calibration re...