Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition

• 主要な著者: Algirdas Mikalkėnas (著者), Bazilė Ravoitytė (著者), Daiva Tauraitė (著者), Elena Servienė (著者), Rolandas Meškys (著者), Saulius Serva (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Small molecule inhibitors have a powerful blocking action on viral polymerases. The bioavailability of the inhibitor, nevertheless, often raise a significant selectivity constraint and may substantially limit the efficacy of therapy. Phosphonoacetic acid has long been known to possess a restricted p...