Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition

• Prif Awduron: Algirdas Mikalkėnas (Awdur), Bazilė Ravoitytė (Awdur), Daiva Tauraitė (Awdur), Elena Servienė (Awdur), Rolandas Meškys (Awdur), Saulius Serva (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Small molecule inhibitors have a powerful blocking action on viral polymerases. The bioavailability of the inhibitor, nevertheless, often raise a significant selectivity constraint and may substantially limit the efficacy of therapy. Phosphonoacetic acid has long been known to possess a restricted p...