Conjugation of phosphonoacetic acid to nucleobase promotes a mechanism-based inhibition
Small molecule inhibitors have a powerful blocking action on viral polymerases. The bioavailability of the inhibitor, nevertheless, often raise a significant selectivity constraint and may substantially limit the efficacy of therapy. Phosphonoacetic acid has long been known to possess a restricted p...
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フォーマット: | 図書 |
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Taylor & Francis Group,
2018-01-01T00:00:00Z.
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A1234.567 |
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