Prostaglandin E2 Impairs P2Y2/P2Y4 Receptor Signaling in Cerebellar Astrocytes via EP3 Receptors

• Main Authors: Lucía Paniagua-Herranz (Author), Juan C. Gil-Redondo (Author), Ma José Queipo (Author), Silvia González-Ramos (Author), Lisardo Boscá (Author), Raquel Pérez-Sen (Author), Ma Teresa Miras-Portugal (Author), Esmerilda G. Delicado (Author)
• 格式: 圖書
• 出版: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Prostaglandin E2 (PGE2) is an important bioactive lipid that accumulates after tissue damage or inflammation due to the rapid expression of cyclooxygenase 2. PGE2 activates specific G-protein coupled EP receptors and it mediates pro- or anti-inflammatory actions depending on the cell-context. Nucleo...