In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat

• Main Authors: Tomonori Shimbo (Author), Takeshi Adachi (Author), Susumu Fujisawa (Author), Mai Hongoh (Author), Takayoshi Ohba (Author), Kyoichi Ono (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lower esophageal sphincter (LES) is a specialized region of the esophageal smooth muscle that allows the passage of a swallowed bolus into the stomach. Nitric oxide (NO) plays a major role in LES relaxation. Nicorandil possesses dual properties of a NO donor and an ATP-sensitive potassium channe...