Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

• Main Authors: Daniel Lindén (Author), Andrea Ahnmark (Author), Piero Pingitore (Author), Ester Ciociola (Author), Ingela Ahlstedt (Author), Anne-Christine Andréasson (Author), Kavitha Sasidharan (Author), Katja Madeyski-Bengtson (Author), Magdalena Zurek (Author), Rosellina M. Mancina (Author), Anna Lindblom (Author), Mikael Bjursell (Author), Gerhard Böttcher (Author), Marcus Ståhlman (Author), Mohammad Bohlooly-Y (Author), William G. Haynes (Author), Björn Carlsson (Author), Mark Graham (Author), Richard Lee (Author), Sue Murray (Author), Luca Valenti (Author), Sanjay Bhanot (Author), Peter Åkerblad (Author), Stefano Romeo (Author)
• Format: Book
• Published: Elsevier, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributor is the patatin-like phospholipase domain-contain...