Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency

• Main Authors: Amée M. Buziau (Author), Maaike H. Oosterveer (Author), Kristiaan Wouters (Author), Trijnie Bos (Author), Dean R. Tolan (Author), Loranne Agius (Author), Brian E. Ford (Author), David Cassiman (Author), Coen D.A. Stehouwer (Author), Casper G. Schalkwijk (Author), Martijn C.G.J. Brouwers (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Stable isotope studies have shown that hepatic de novo lipogenesis (DNL) plays an important role in the pathogenesis of intrahepatic lipid (IHL) deposition. Furthermore, previous research has demonstrated that fructose 1-phosphate (F1P) not only serves as a substrate for DNL, but also act...