Preclinical evaluation and automated synthesis of [89Zr]ZrDFOSquaramide-girentuximab for diagnostic imaging of carbonic anhydrase IX positive tumours

• Egile Nagusiak: Asif Noor (Egilea), Emily R. McGowan (Egilea), Jessica K. Van Zuylekom (Egilea), Carleen Cullinane (Egilea), Peter D. Roselt (Egilea), Rodney J. Hicks (Egilea), Michael P. Wheatcroft (Egilea), Paul S. Donnelly (Egilea)
• Formatua: Liburua
• Argitaratua: SpringerOpen, 2024-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Carbonic Anhydrase IX (CAIX) is a zinc metalloenzyme that is over-expressed in many cancers making it a valid target for targeted diagnostic imaging with Positron Emission Tomography (PET). The monoclonal antibody girentuximab binds to CAIX and when radiolabelled with positron-em...