Preclinical evaluation and automated synthesis of [89Zr]ZrDFOSquaramide-girentuximab for diagnostic imaging of carbonic anhydrase IX positive tumours

• Main Authors: Asif Noor (Author), Emily R. McGowan (Author), Jessica K. Van Zuylekom (Author), Carleen Cullinane (Author), Peter D. Roselt (Author), Rodney J. Hicks (Author), Michael P. Wheatcroft (Author), Paul S. Donnelly (Author)
• Format: Book
• Published: SpringerOpen, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Carbonic Anhydrase IX (CAIX) is a zinc metalloenzyme that is over-expressed in many cancers making it a valid target for targeted diagnostic imaging with Positron Emission Tomography (PET). The monoclonal antibody girentuximab binds to CAIX and when radiolabelled with positron-em...