Doxycycline Attenuates Cancer Cell Growth by Suppressing NLRP3-Mediated Inflammation

• Main Authors: Mohammad Alsaadi (Author), Gulcin Tezcan (Author), Ekaterina E. Garanina (Author), Shaimaa Hamza (Author), Alan McIntyre (Author), Albert A. Rizvanov (Author), Svetlana F. Khaiboullina (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NLR family pyrin domain containing 3 (NLRP3) inflammasome formation is triggered by the damaged mitochondria releasing reactive oxygen species. Doxycycline was shown to regulate inflammation; however, its effect on NLRP3 in cancer remains largely unknown. Therefore, we sought to determine the effect...