SIRT6 Activator UBCS039 Inhibits Thioacetamide-Induced Hepatic Injury In Vitro and In Vivo

• Ngā kaituhi matua: Fangzhou Jiao (Author), Zongwei Zhang (Author), Hongtu Hu (Author), Yongxi Zhang (Author), Yong Xiong (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

SIRT6 has been reported to have multiple functions in inflammation and metabolism. In the present study, we explored the regulatory effects and mechanisms of SIRT6 in thioacetamide (TAA)-induced mice acute liver failure (ALF) models. The SIRT6 activator UBCS039 was used in this animal and cell exper...