Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE

• Hauptverfasser: Lucía F. Zacchi (Verfasst von), John C. Dittmar (Verfasst von), Michael J. Mihalevic (Verfasst von), Annette M. Shewan (Verfasst von), Benjamin L. Schulz (Verfasst von), Jeffrey L. Brodsky (Verfasst von), Kara A. Bernstein (Verfasst von)
• Format: Buch
• Veröffentlicht: The Company of Biologists, 2017-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of dystonia is early-onset torsion dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinAΔE, is a deletion of a C-terminal glutamate residu...