Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE

• Main Authors: Lucía F. Zacchi (Author), John C. Dittmar (Author), Michael J. Mihalevic (Author), Annette M. Shewan (Author), Benjamin L. Schulz (Author), Jeffrey L. Brodsky (Author), Kara A. Bernstein (Author)
• Format: Book
• Published: The Company of Biologists, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of dystonia is early-onset torsion dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinAΔE, is a deletion of a C-terminal glutamate residu...