Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury

• Main Authors: Yogesh Scindia (Author), Ewa Wlazlo (Author), Joseph Leeds (Author), Valentina Loi (Author), Jonathan Ledesma (Author), Sylvia Cechova (Author), Elizabeth Ghias (Author), Sundararaman Swaminathan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepcidin induces iron sequestration to limit iron avai...