Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across Rat Skin

• मुख्य लेखकों: Harunobu Iwase (लेखक), Mitsuru Hashimoto (लेखक), Yuko Takase (लेखक), Teruko Imai (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2013-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity of dermal hydrolases has rarely been investigated in humans, or experimental animals. In the present study, we focused on the ident...