Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across Rat Skin

• Váldodahkkit: Harunobu Iwase (Dahkki), Mitsuru Hashimoto (Dahkki), Yuko Takase (Dahkki), Teruko Imai (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2013-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity of dermal hydrolases has rarely been investigated in humans, or experimental animals. In the present study, we focused on the ident...