Thyroid hormone receptor beta (THRβ1) is the major regulator of T3 action in human iPSC-derived hepatocytes

• Hauptverfasser: Lorraine Soares De Oliveira (Verfasst von), Joseph E. Kaserman (Verfasst von), Anne H. Van Der Spek (Verfasst von), Nora J. Lee (Verfasst von), Hendrik J. Undeutsch (Verfasst von), Rhiannon B. Werder (Verfasst von), Andrew A. Wilson (Verfasst von), Anthony N. Hollenberg (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2024-12-01T00:00:00Z.
• Schlagworte: article
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Objective: Thyroid hormone (TH) action is mediated by thyroid hormone receptor (THR) isoforms. While THRβ1 is likely the main isoform expressed in liver, its role in human hepatocytes is not fully understood. Methods: To elucidate the role of THRβ1 action in human hepatocytes we used CRISPR/Cas9 edi...