Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia

• Main Authors: Matias Estaras (Author), Manuel R. Gonzalez-Portillo (Author), Remigio Martinez (Author), Alfredo Garcia (Author), Mario Estevez (Author), Miguel Fernandez-Bermejo (Author), Jose M. Mateos (Author), Daniel Vara (Author), Gerardo Blanco-Fernández (Author), Diego Lopez-Guerra (Author), Vicente Roncero (Author), Gines M. Salido (Author), Antonio Gonzalez (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic stellate cells (PSC) play a major role in the formation of fibrotic tissue in pancreatic tumors. On its side, melatonin is a putative therapeutic agent for pancreatic cancer and inflammation. In this work, the actions of melatonin on PSC subjected to hypoxia were evaluated. Reactive oxyge...