Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling

• Main Authors: Dan-Qin Sun (Author), Fuqiang Yuan (Author), Meng-Zhu Fu (Author), Meng-Yang Zhong (Author), Shi-Liang Zhang (Author), Yan Lu (Author), Giovanni Targher (Author), Christopher D. Byrne (Author), Ming-Hua Zheng (Author), Wei-Jie Yuan (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Activation of farnesoid X receptor (FXR), a bile acid nuclear receptor, may be implicated in the pathophysiology of diabetic nephropathy. We explored a possible role for FXR activation in preventing renal fibrosis in high fat diet (HFD)-fed mice. Methods: We investigated the effects of HF...