Development and Evaluation of Poorly Water-Soluble Celecoxib as Solid Dispersions Containing Nonionic Surfactants Using Fluidized-Bed Granulation

• Main Authors: Hyeok Jin Kwon (Author), Eun-Ji Heo (Author), Young-Hwan Kim (Author), Sarah Kim (Author), Young-Ha Hwang (Author), Ji-Mi Byun (Author), Se Hyeop Cheon (Author), Sang Yeob Park (Author), Dong Yun Kim (Author), Kwan Hyung Cho (Author), Han-Joo Maeng (Author), Dong-Jin Jang (Author)
• Format: Book
• Published: MDPI AG, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study is to develop a solid dispersion system with improved dissolution, absorption, and patient compliance of poorly water-soluble celecoxib (CXB). Instead of sodium lauryl sulfate (SLS), an anionic surfactant used in the marketed product (Celebrex<sup>&#174;</sup&g...