Particle size affects pharmacokinetics of milled oxycodone hydrochloride tablet products following nasal insufflation in nondependent, recreational opioid users

• Main Authors: Saeid Raofi (Author), Minori Kinjo (Author), Dajun Sun (Author), Zhichuan Li (Author), Heather Boyce (Author), Karthika Natarajan (Author), Mitchell Frost (Author), Liang Zhao (Author), Markham Luke (Author), Robert Lionberger (Author), Debra Kelsh (Author), Myong‐Jin Kim (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study assessed the impact of product particle sizes (fine: 106-500 µm; coarse: 500-1000 µm) on oxycodone pharmacokinetics (PK) following nasal insufflation of milled oxycodone extended‐release (ER) abuse‐deterrent (AD) tablets using immediate‐release (IR) non‐AD product as reference. A...