DENV-3 precursor membrane (prM) glycoprotein enhances E protein immunogenicity and confers protection against DENV-2 infections in a murine model

• Main Authors: Roberto S. Dias (Author), Michelle D. Teixeira (Author), Mariana F. Xisto (Author), John W. O. Prates (Author), Jessica D. Da Silva (Author), Iago O. Mello (Author), Cynthia C. Da Silva (Author), Sérgio O. De Paula (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To improve a DNA vaccine containing the truncated dengue virus serotype 2 (DENV-2) envelope (E) protein and evaluate the influence of precursor membrane (prM) glycoprotein polymorphism on E protein immunogenicity, two vaccine candidates have been constructed by upstream insertion of the DENV-2 and D...