Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K₂₍₂₀₎, on All-Trans Retinoic Acid-Resistant HL60 Cell Line

• Main Authors: Hirofumi Yamakawa (Author), Shuichi Setoguchi (Author), Shotaro Goto (Author), Daisuke Watase (Author), Kazuki Terada (Author), Nami Nagata-Akaho (Author), Erina Toki (Author), Mitsuhisa Koga (Author), Kazuhisa Matsunaga (Author), Yoshiharu Karube (Author), Jiro Takata (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The first-choice drug for acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA), frequently causes drug-resistance and some adverse effects. Thus, an effective and safe agent for ATRA-resistant APL is needed. Menaquinone-4 (MK-4, vitamin K₂₍₂₀₎), used for osteopor...