Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

• Główni autorzy: Traian Sulea (Autor), Nazanin Rohani (Autor), Jason Baardsnes (Autor), Christopher R. Corbeil (Autor), Christophe Deprez (Autor), Yuneivy Cepero-Donates (Autor), Alma Robert (Autor), Joseph D. Schrag (Autor), Marie Parat (Autor), Mélanie Duchesne (Autor), Maria L. Jaramillo (Autor), Enrico O. Purisima (Autor), John C. Zwaagstra (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Potent targeting and/or effector activities on normal tissues is an obvious toxicity concern. Optimization of specific tumor targeting could be achieved by taki...