Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment
Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Potent targeting and/or effector activities on normal tissues is an obvious toxicity concern. Optimization of specific tumor targeting could be achieved by taki...
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Formato: | Livro |
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Taylor & Francis Group,
2020-01-01T00:00:00Z.
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