Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment

• Main Authors: Traian Sulea (Author), Nazanin Rohani (Author), Jason Baardsnes (Author), Christopher R. Corbeil (Author), Christophe Deprez (Author), Yuneivy Cepero-Donates (Author), Alma Robert (Author), Joseph D. Schrag (Author), Marie Parat (Author), Mélanie Duchesne (Author), Maria L. Jaramillo (Author), Enrico O. Purisima (Author), John C. Zwaagstra (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Potent targeting and/or effector activities on normal tissues is an obvious toxicity concern. Optimization of specific tumor targeting could be achieved by taki...